The role of C-terminal tensin-like (Cten) gene in cancer metastasis

Saleh Alghamdi; Sarah Alkwai; Mohammad Ilyas

doi:10.24911/JBCGenetics/183-1531548689

2023, Vol: 6, Issue: 2

6 / 2Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

Title Page

« Previous Article

Review Article

JBCGenetics. 2018; 1(1): 2-9

doi: 10.24911/JBCGenetics/183-1531548689

The role of C-terminal tensin-like (Cten) gene in cancer metastasis

Saleh Alghamdi, Sarah Alkwai, Mohammad Ilyas.

Abstract
C-terminal tensin-like (cten, also known as tensin4, TNS4) is the fourth member of the tensin family. all tensin family members localizes in focal adhesion sites. Cten shares the sequence homology with other tensins at its C-terminal region by having the SH2 and PTB domains. Cten is expressed in some normal tissue such as prostate and placenta while down-regulated in prostate cancer. The overexpression of cten was found associates with tumors of breast, colon, lung, stomach, skin and pancreas. It interacts with growth factors and cytokines as regulators. Also it has been found that cten expression promotes cell motility and enhances tumorigenicity. The collective findings support that cten is having a role in carcinogenesis and promising biomarker. It can be a candidate for a therapeutic target for solid cancers.

Key words: Cten, colorectal cancer, tensin, metastasis

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Saleh Alghamdi Articles by Sarah Alkwai Articles by Mohammad Ilyas
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Alghamdi S, Alkwai S, Ilyas M. The role of C-terminal tensin-like (Cten) gene in cancer metastasis. JBCGenetics. 2018; 1(1): 2-9. doi:10.24911/JBCGenetics/183-1531548689

Web Style

Alghamdi S, Alkwai S, Ilyas M. The role of C-terminal tensin-like (Cten) gene in cancer metastasis. https://www.jbcgenetics.com/?mno=978 [Access: March 13, 2024]. doi:10.24911/JBCGenetics/183-1531548689

AMA (American Medical Association) Style

Alghamdi S, Alkwai S, Ilyas M. The role of C-terminal tensin-like (Cten) gene in cancer metastasis. JBCGenetics. 2018; 1(1): 2-9. doi:10.24911/JBCGenetics/183-1531548689

Vancouver/ICMJE Style

Alghamdi S, Alkwai S, Ilyas M. The role of C-terminal tensin-like (Cten) gene in cancer metastasis. JBCGenetics. (2018), [cited March 13, 2024]; 1(1): 2-9. doi:10.24911/JBCGenetics/183-1531548689

Harvard Style

Alghamdi, S., Alkwai, . S. & Ilyas, . M. (2018) The role of C-terminal tensin-like (Cten) gene in cancer metastasis. JBCGenetics, 1 (1), 2-9. doi:10.24911/JBCGenetics/183-1531548689

Turabian Style

Alghamdi, Saleh, Sarah Alkwai, and Mohammad Ilyas. 2018. The role of C-terminal tensin-like (Cten) gene in cancer metastasis. Journal of Biochemical and Clinical Genetics, 1 (1), 2-9. doi:10.24911/JBCGenetics/183-1531548689

Chicago Style

Alghamdi, Saleh, Sarah Alkwai, and Mohammad Ilyas. "The role of C-terminal tensin-like (Cten) gene in cancer metastasis." Journal of Biochemical and Clinical Genetics 1 (2018), 2-9. doi:10.24911/JBCGenetics/183-1531548689

MLA (The Modern Language Association) Style

Alghamdi, Saleh, Sarah Alkwai, and Mohammad Ilyas. "The role of C-terminal tensin-like (Cten) gene in cancer metastasis." Journal of Biochemical and Clinical Genetics 1.1 (2018), 2-9. Print. doi:10.24911/JBCGenetics/183-1531548689

APA (American Psychological Association) Style

Alghamdi, S., Alkwai, . S. & Ilyas, . M. (2018) The role of C-terminal tensin-like (Cten) gene in cancer metastasis. Journal of Biochemical and Clinical Genetics, 1 (1), 2-9. doi:10.24911/JBCGenetics/183-1531548689

Most Viewed Articles

Most Accessed Articles

Frontonasal dysplasia: a review
Muhammad Umair, Farooq Ahmad, Muhammad Bilal, Muhammad Arshad
JBCGenetics. 2018; 1(2): 66-76
» Abstract » doi: 10.24911/JBCGenetics/183-1530765389

The role of C-terminal tensin-like (Cten) gene in cancer metastasis
Saleh Alghamdi, Sarah Alkwai, Mohammad Ilyas
JBCGenetics. 2018; 1(1): 2-9
» Abstract » doi: 10.24911/JBCGenetics/183-1531548689

Clinical reassessment of post-laboratory variant call format (VCF) files
Lamia Alsubaie, Saeed Alturki, Ali Alothaim, Ahmed Alfares
JBCGenetics. 2018; 1(1): 31-36
» Abstract » doi: 10.24911/JBCGenetics/183-1529928114

Microcephalic osteodysplastic primordial dwarfism type II and Klinefelter syndrome: report of two competing growth syndromes
AlAnoud Al-Jarbou, Afnan Al-Turki, Suha Tashkandi, Eissa A. Faqeih
JBCGenetics. 2018; 1(1): 37-39
» Abstract » doi: 10.24911/JBCGenetics/183-1530040885

Recessive ARFGEF2 mutation causes progressive microcephaly, epilepsy, and a distinct MRI pattern
Maram Alojair, Abdulaziz Alghamdi, Kalthoum Tlili, Sateesh Maddirevula, Fowzan Sami Alkuraya, Brahim Tabarki
JBCGenetics. 2018; 1(1): 40-42
» Abstract » doi: 10.24911/JBCGenetics/183-1531469195

Most Downloaded

Top Downloaded Articles

Frontonasal dysplasia: a review
Muhammad Umair, Farooq Ahmad, Muhammad Bilal, Muhammad Arshad
JBCGenetics. 2018; 1(2): 66-76
» Abstract » doi: 10.24911/JBCGenetics/183-1530765389

Generation of a mouse model of Primary Hyperoxaluria Type 1 via CRISPR/Cas9 mediated gene editing
Kimberly A Coughlan, Rajanikanth J Maganti, Andrea Frassetto, Christine M DeAntonis, meredith Wolfrom, Anne-Renee Graham, Shawn M Hillier, Steven Fortucci, Hoor Al Jandal, Sue-Jean Hong, Paloma H Giangrande, Paolo GV Martini,
JBCGenetics. 2019; 2(1): 28-39
» Abstract » doi: 10.24911/JBCGenetics/183-1542047633

Syndactyly genes and classification: a mini review
Muhammad Umair, Farooq Ahmad, Muhammad Bilal, Safdar Abbas
JBCGenetics. 2018; 1(1): 10-18
» Abstract » doi: 10.24911/JBCGenetics/183-1532177257

Consanguinity, awareness, and genetic disorders among female university students in Riyadh, Saudi Arabia
Hadil Alahdal, Huda Alshanbari, Hana Saud Almazroa, Sarah Majed Alayesh, Alaa Mohammad Alrhaili, Nora Alqubi, Fai Fahad Alzamil, Reem Albassam
JBCGenetics. 2021; 4(1): 27-34
» Abstract » doi: 10.24911/JBCGenetics/183-1601264923

Most Cited Articles

Most Cited Articles

Frontonasal dysplasia: a review
Muhammad Umair, Farooq Ahmad, Muhammad Bilal, Muhammad Arshad
JBCGenetics. 2018; 1(2): 66-76
» Abstract » doi: 10.24911/JBCGenetics/183-1530765389
Cited : 4 times [Click to see citing articles]

Genomics in Saudi Arabia Call for Data-Sharing Policy
Ahmed Alfares,
JBCGenetics. 2018; 1(2): 51-52
» Abstract » doi: 10.24911/JBCGenetics/183-1546945268
Cited : 4 times [Click to see citing articles]

Harel-Yoon syndrome: the first case report from Saudi Arabia
Alaa AlAyed, Manar A. Samman, Abdul Ali Peer-Zada, Mohammed Almannai
JBCGenetics. 2020; 3(1): 22-27
» Abstract » doi: 10.24911/JBCGenetics/183-1585816398
Cited : 2 times [Click to see citing articles]

About Journal of Biochemical and Clinical Genetics

The Journal of Biochemical and Clinical Genetics (JBCGenetics) is a peer-reviewed, open access medical journal. Owner: Saudi Society of Medical ... Read more.

For best results, please use Internet Explorer or Google Chrome.

Contact Information

Title Owner: Saudi Society of Medical Genetics

https://ssmg.org.sa/en

Society Email: info@ssmg.org.sa

Editor in Chief: dralfadhelm@jbcgenetics.com

Contact the publisher:

contact@discoverpublish.com
https://discoverpublish.com/

Publisher: Discover STM Publishing Ltd,

82 Leslie's Arch, Old Quarter, Ballincollig, Cork, P31 RY62, Ireland.

Hours: M-F: 8:30am - 5:30pm

Contact Emails:

Journal Editorial Office: contact@jbcgenetics.com

Billing Support: contact@discoverpublish.com

Technical Support:
anastasiia.pavlenco@sofiafields.com
https://sofiafields.com/

POLICIES & JOURNAL LINKS

About Journal of Biochemical and Clinical Genetics

Contact Information

How to cite this article