Review Article
Volume: 1 | Issue: 1 | Published: Jan 01, 1970 | Pages: 19 - 25 | DOI: 10.24911/JBCGenetics/183-1529935373
Molecular genetics of inherited kidney disease in Saudi Arabia
Authors: Mohamed H Al-Hamed , Faiqa Imtiaz , Jameela Kari
Article Info
Authors
Mohamed H Al-Hamed
Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabi
Faiqa Imtiaz
Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Jameela Kari
Pediatric Nephrology Center of Excellence and Pediatric Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
Publication History
Received: November 23, 2017
Revised: December 13, 2017
Accepted: December 19, 2017
Published: January 01, 1970
Abstract
Human kidneys serve important physiological functions in the body. There is an increasing evidence suggesting that the majority of renal diseases have an underlying genetic component. At least 40 genes have been shown to be involved in kidney development and many more genes are expressed within the kidney and regulate renal physiology. It is observed that genetic and congenital disorders are more common in Arab countries than in industrialized countries. Saudi Arabia is the largest Arab country and estimation of patients with end-stage kidney failure is 136 for each million yearly. Preliminary observations indicate that children in Saudi Arabia probably have a higher incidence of polycystic kidney disease, familial juvenile nephronophthisis, congenital urological anomalies, and familial nephrotic syndrome. Molecular diagnosis would help enormously in prevention and introduce early management which could ensure a better outcome. This is a review article of molecular studies conducted in the Kingdom of Saudi Arabia from 1990 till present time to elucidate disease-causing genes of inherited kidney disease.
Keywords: Inherited kidney disease, mutations, molecular genetics, consanguinity, Saudi Arabia
Pubmed Style
Mohamed H Al-Hamed, Faiqa Imtiaz, Jameela Kari. Molecular genetics of inherited kidney disease in Saudi Arabia. JBC Genetics. 1970; 01 (January 1970): 19-25. doi:10.24911/JBCGenetics/183-1529935373
Web Style
Mohamed H Al-Hamed, Faiqa Imtiaz, Jameela Kari. Molecular genetics of inherited kidney disease in Saudi Arabia. https://www.jbcgenetics.com/index.php/articles/2014 [Access: April 27, 2025]. doi:10.24911/JBCGenetics/183-1529935373
AMA (American Medical Association) Style
Mohamed H Al-Hamed, Faiqa Imtiaz, Jameela Kari. Molecular genetics of inherited kidney disease in Saudi Arabia. JBC Genetics. 1970; 01 (January 1970): 19-25. doi:10.24911/JBCGenetics/183-1529935373
Vancouver/ICMJE Style
Mohamed H Al-Hamed, Faiqa Imtiaz, Jameela Kari. Molecular genetics of inherited kidney disease in Saudi Arabia. JBC Genetics. (1970), [cited April 27, 2025]; 01 (January 1970): 19-25. doi:10.24911/JBCGenetics/183-1529935373
Harvard Style
Mohamed H Al-Hamed, Faiqa Imtiaz, Jameela Kari (1970) Molecular genetics of inherited kidney disease in Saudi Arabia. JBC Genetics, 01 (January 1970): 19-25. doi:10.24911/JBCGenetics/183-1529935373
Chicago Style
Mohamed H Al-Hamed, Faiqa Imtiaz, Jameela Kari. "Molecular genetics of inherited kidney disease in Saudi Arabia." 01 (1970), 19-25. doi:10.24911/JBCGenetics/183-1529935373
MLA (The Modern Language Association) Style
Mohamed H Al-Hamed, Faiqa Imtiaz, Jameela Kari. "Molecular genetics of inherited kidney disease in Saudi Arabia." 01.January 1970 (1970), 19-25. Print. doi:10.24911/JBCGenetics/183-1529935373
APA (American Psychological Association) Style
Mohamed H Al-Hamed, Faiqa Imtiaz, Jameela Kari (1970) Molecular genetics of inherited kidney disease in Saudi Arabia. , 01 (January 1970), 19-25. doi:10.24911/JBCGenetics/183-1529935373