Review Article
Volume: 4 | Issue: 1 | Published: Nov 19, 2020 | Pages: 42 - 47 | DOI: 10.24911/JBCGenetics/183-1597317668
The association between IVF and chromosomal abnormalities compared to spontaneous conception
Authors: Sawsan Alharthi , Lama Alrasheed , Ghada Alrashed , Ghaida Almutairi , Marwan Nashabat , Majid Alfadhel
Article Info
Authors
Sawsan Alharthi
College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City Ministry of National Guard-Health Affairs (MNG-HA), Riyadh, Saudi Arabia
Lama Alrasheed
College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City Ministry of National Guard-Health Affairs (MNG-HA), Riyadh, Saudi Arabia
Ghada Alrashed
College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City Ministry of National Guard-Health Affairs (MNG-HA), Riyadh, Saudi Arabia
Ghaida Almutairi
College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City Ministry of National Guard-Health Affairs (MNG-HA), Riyadh, Saudi Arabia
Marwan Nashabat
Medical Genetics Division, Department of Pediatrics, King Abdulaziz Medical City Ministry of National Guard-Health Affairs (MNG-HA), Riyadh, Saudi Arabia
Majid Alfadhel
College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City Ministry of National Guard-Health Affairs (MNG-HA), Riyadh, Saudi Arabia
Publication History
Received: August 13, 2020
Revised: October 18, 2020
Accepted: October 28, 2020
Published: November 19, 2020
Abstract
In vitro fertilization (IVF) is a process by which an egg is extracted by needle aspiration and then combined with a sperm so that fertilization can occur outside the body. Genetic defects, such as chromosomal abnormalities, are considered rare among the general population; however, even though their incidence among IVF-conceived children is uncommon, several alarming studies were published on the increased risk of chromosomal abnormalities IVF/intracytoplasmic sperm injection (ICSI)-conceived children compared to universal rates. This study aimed to review the literature and present data to answer whether IVF or ICSI is associated with an increased risk of chromosomal abnormalities inborn after IVF/ICSI treatment compared to spontaneously conceived children. Relevant published scientific articles were searched in the Medline database, using combinations of the following key terms: "IVF", "in vitro fertilization", "ICSI", "intracytoplasmic sperm injection", "natural conception", "spontaneous conception" along with "chromosomal abnormalities", "chromosomal defects", "sex chromosome aneuploidy", and "trisomy". The eligible studies were considered as studies exploring the association of IVF/ICSI with chromosomal abnormalities compared to spontaneous conception. The search included studies published from 1992 to 2018. The results for the association of chromosomal abnormalities and IVF remain unclear. As many studies proved a significant increase in chromosomal abnormalities and syndromes among the IVF population, other studies were contradicting and contributed the abnormalities to several environmental and technical factors.
Keywords: IVF, ICSI, spontaneous conception, chromosomal abnormalities, sex chromosome aneuploidy, trisomy
Pubmed Style
Sawsan Alharthi, Lama Alrasheed, Ghada Alrashed, Ghaida Almutairi, Marwan Nashabat, Majid Alfadhel. The association between IVF and chromosomal abnormalities compared to spontaneous conception. JBC Genetics. 2020; 19 (November 2020): 42-47. doi:10.24911/JBCGenetics/183-1597317668
Web Style
Sawsan Alharthi, Lama Alrasheed, Ghada Alrashed, Ghaida Almutairi, Marwan Nashabat, Majid Alfadhel. The association between IVF and chromosomal abnormalities compared to spontaneous conception. https://www.jbcgenetics.com/index.php/articles/2128 [Access: April 27, 2025]. doi:10.24911/JBCGenetics/183-1597317668
AMA (American Medical Association) Style
Sawsan Alharthi, Lama Alrasheed, Ghada Alrashed, Ghaida Almutairi, Marwan Nashabat, Majid Alfadhel. The association between IVF and chromosomal abnormalities compared to spontaneous conception. JBC Genetics. 2020; 19 (November 2020): 42-47. doi:10.24911/JBCGenetics/183-1597317668
Vancouver/ICMJE Style
Sawsan Alharthi, Lama Alrasheed, Ghada Alrashed, Ghaida Almutairi, Marwan Nashabat, Majid Alfadhel. The association between IVF and chromosomal abnormalities compared to spontaneous conception. JBC Genetics. (2020), [cited April 27, 2025]; 19 (November 2020): 42-47. doi:10.24911/JBCGenetics/183-1597317668
Harvard Style
Sawsan Alharthi, Lama Alrasheed, Ghada Alrashed, Ghaida Almutairi, Marwan Nashabat, Majid Alfadhel (2020) The association between IVF and chromosomal abnormalities compared to spontaneous conception. JBC Genetics, 19 (November 2020): 42-47. doi:10.24911/JBCGenetics/183-1597317668
Chicago Style
Sawsan Alharthi, Lama Alrasheed, Ghada Alrashed, Ghaida Almutairi, Marwan Nashabat, Majid Alfadhel. "The association between IVF and chromosomal abnormalities compared to spontaneous conception." 19 (2020), 42-47. doi:10.24911/JBCGenetics/183-1597317668
MLA (The Modern Language Association) Style
Sawsan Alharthi, Lama Alrasheed, Ghada Alrashed, Ghaida Almutairi, Marwan Nashabat, Majid Alfadhel. "The association between IVF and chromosomal abnormalities compared to spontaneous conception." 19.November 2020 (2020), 42-47. Print. doi:10.24911/JBCGenetics/183-1597317668
APA (American Psychological Association) Style
Sawsan Alharthi, Lama Alrasheed, Ghada Alrashed, Ghaida Almutairi, Marwan Nashabat, Majid Alfadhel (2020) The association between IVF and chromosomal abnormalities compared to spontaneous conception. , 19 (November 2020), 42-47. doi:10.24911/JBCGenetics/183-1597317668