JBCGenetics |

Case Report

Volume: 6 | Issue: 1 | Published: Feb 25, 2023 | Pages: 70 - 74 | DOI: 10.24911/JBCGenetics/183-1668575222

Dilated cardiomyopathy associated with NRAP gene: a case series

Authors: Abdellh A. Names , Mohammed A. Tohary , Basel A. Hadad , Abdurahman H. Alhazmi , Hamad M. Alaksham , Hassan M. Gohal , Ghadah M. Gosadi , Ali A. Awaji , Mohammad A. Jareebi

Article Info

Authors

Abdellh A. Names

Medical student, Jazan University, Jazan, Saudi Arabi

Mohammed A. Tohary

Consultant Medical Genetic and Metabolic Disorders, Prince Mohammed Bin Nasser Hospital, Jazan, Saudi Arabia

Basel A. Hadad

Consultant Pediatric Cardiologist, Prince Mohammed Bin Nasser Hospital, Jazan, Saudi Arabia

Abdurahman H. Alhazmi

Consultant Pediatric Cardiologist, Prince Mohammed Bin Nasser Hospital, Jazan, Saudi Arabia

Hamad M. Alaksham

Consultant Pediatric Cardiologist, Prince Mohammed Bin Nasser Hospital, Jazan, Saudi Arabia

Hassan M. Gohal

Consultant Pediatric Intensive Care, Prince Mohammed Bin Nasser Hospital, Jazan, Saudi Arabia

Ghadah M. Gosadi

Consultant Medical Genetic and Metabolic Disorders, Prince Mohammed Bin Nasser Hospital, Jazan, Saudi Arabia

Ali A. Awaji

Consultant Medical Genetic and Metabolic Disorders, Prince Mohammed Bin Nasser Hospital, Jazan, Saudi Arabia

Mohammad A. Jareebi

Lecturer, Jazan University, Jazan, Saudi Arabia.

ORCID

Publication History

Received: November 16, 2022

Revised: January 18, 2023

Accepted: January 24, 2023

Published: February 25, 2023

Abstract

Background: The genetic basis of dilated cardiomyopathy (DCM) is highly diverse, with over 100 known genes and several possibilities described. Nebulin-related-anchoring protein (NRAP) is an action-binding cytoskeletal protein that has a role in the myofibrillar assembly in the embryonic heart. It is primarily generated in striated and cardiac muscles. Case Presentation: We described three cases of DCM that were related to NRAP gene mutations [NM_001261463.1: c.3568G > T; p. (Glu1190*)]. Conclusion: Our data imply that biallelic nonsense mutations in the NRAP might be a genetic risk factor with limited penetrance and induce DCM at various ages.

Keywords: NRAP gene, heart failure, cardiomyopathies, DCM, genetics

Pubmed Style

Abdellh A. Names, Mohammed A. Tohary, Basel A. Hadad, Abdurahman H. Alhazmi, Hamad M. Alaksham, Hassan M. Gohal, Ghadah M. Gosadi, Ali A. Awaji, Mohammad A. Jareebi. Dilated cardiomyopathy associated with NRAP gene: a case series. JBC Genetics. 2023; 25 (February 2023): 70-74. doi:10.24911/JBCGenetics/183-1668575222

Web Style

Abdellh A. Names, Mohammed A. Tohary, Basel A. Hadad, Abdurahman H. Alhazmi, Hamad M. Alaksham, Hassan M. Gohal, Ghadah M. Gosadi, Ali A. Awaji, Mohammad A. Jareebi. Dilated cardiomyopathy associated with NRAP gene: a case series. https://www.jbcgenetics.com/index.php/articles/2084 [Access: April 27, 2025]. doi:10.24911/JBCGenetics/183-1668575222

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Abdellh A. Names, Mohammed A. Tohary, Basel A. Hadad, Abdurahman H. Alhazmi, Hamad M. Alaksham, Hassan M. Gohal, Ghadah M. Gosadi, Ali A. Awaji, Mohammad A. Jareebi. Dilated cardiomyopathy associated with NRAP gene: a case series. JBC Genetics. (2023), [cited April 27, 2025]; 25 (February 2023): 70-74. doi:10.24911/JBCGenetics/183-1668575222

Harvard Style

Abdellh A. Names, Mohammed A. Tohary, Basel A. Hadad, Abdurahman H. Alhazmi, Hamad M. Alaksham, Hassan M. Gohal, Ghadah M. Gosadi, Ali A. Awaji, Mohammad A. Jareebi (2023) Dilated cardiomyopathy associated with NRAP gene: a case series. JBC Genetics, 25 (February 2023): 70-74. doi:10.24911/JBCGenetics/183-1668575222

Chicago Style

Abdellh A. Names, Mohammed A. Tohary, Basel A. Hadad, Abdurahman H. Alhazmi, Hamad M. Alaksham, Hassan M. Gohal, Ghadah M. Gosadi, Ali A. Awaji, Mohammad A. Jareebi. "Dilated cardiomyopathy associated with NRAP gene: a case series." 25 (2023), 70-74. doi:10.24911/JBCGenetics/183-1668575222

MLA (The Modern Language Association) Style

Abdellh A. Names, Mohammed A. Tohary, Basel A. Hadad, Abdurahman H. Alhazmi, Hamad M. Alaksham, Hassan M. Gohal, Ghadah M. Gosadi, Ali A. Awaji, Mohammad A. Jareebi. "Dilated cardiomyopathy associated with NRAP gene: a case series." 25.February 2023 (2023), 70-74. Print. doi:10.24911/JBCGenetics/183-1668575222

APA (American Psychological Association) Style

Abdellh A. Names, Mohammed A. Tohary, Basel A. Hadad, Abdurahman H. Alhazmi, Hamad M. Alaksham, Hassan M. Gohal, Ghadah M. Gosadi, Ali A. Awaji, Mohammad A. Jareebi (2023) Dilated cardiomyopathy associated with NRAP gene: a case series. , 25 (February 2023), 70-74. doi:10.24911/JBCGenetics/183-1668575222