JBCGenetics |

Original Article

Volume: 6 | Issue: 2 | Published: Feb 04, 2024 | Pages: 097 - 105 | DOI: 10.24911/JBCGenetics/183-1674209873

Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma

Authors: Qing Yue , Wei Han , Ziling Liu , Zain Abbas , Akmal Zubair , Saba Beigh , Hayaa Mohammad Alhuthali , Hind A. Alzahrani , Rasha Mohammed Saleem , Nahed S. Alharthi

Article Info

Authors

Qing Yue

Department of Oncology, the First Hospital of Jilin University, Changchun 130021, Jilin, China

Wei Han

Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, Changchun 130021, Jilin, China

Ziling Liu

Department of Oncology, the First Hospital of Jilin University, Changchun 130021, Jilin, China

Zain Abbas

Department of Life Sciences, University of Management and Technology, Lahore, Pakistan

Akmal Zubair

Department of Biotechnology, Quaid-e-Azam university Islamabad, Pakistan

Saba Beigh

Department of Public Health, Faculty of Applied Medical Sciences, Albaha University, Albaha 65431, Saudi Arabia

Hayaa Mohammad Alhuthali

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia

Hind A. Alzahrani

Basic sciences, College of Applied of Medical Sciences, Albaha University, Albaha:4781:Saudi Arabia

Rasha Mohammed Saleem

Rasha Mohammed Saleem Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Albaha 65431, Saudi Arabia

Nahed S. Alharthi

Department of Medical Laboratory Sciences. College of Applied Medical Sciences in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudia Arabia.

Publication History

Received: January 30, 2023

Accepted: January 12, 2024

Published: February 04, 2024

Abstract

Abstract Purpose: The purpose of this paper is to construct and validate the immune-related prognostic signature in lung squamous cell carcinoma through integrated bioinformatics analysis. Methods: We constructed an optimized prognostic risk model consisting of five PIR-lncRNAs (AC107884.1, LCMT1-AS1, AL163051.1, AC005730.3 and LINC02635). We then performed survival analysis and independent prognostic analysis on the prognostic risk model to assess and validate the prognostic value of the model. Further, we performed differential analysis of immune cell infiltration between high- and low-risk patients in the model. Results: In this article, we obtained 546 differentially expressed genes and 21 immune-related genes, identified 654 immune-related lncRNAs (IR-lncRNAs) by co-expression network analysis, and identified 18 prognostic IR-lncRNAs (PIR-lncRNAs) by univariate Cox analysis. Through the analysis of immune escape and immunotherapy, we verified that the effect of immunotherapy in high-risk group patients may be lower. Conclusion: Our findings elucidate the intrinsic molecular biological link between the pathogenic genes of lung squamous cell carcinoma (LUSC) and immune cells, which has important exploration and reference significance for the precise and potential immunotherapy of LUSC patients, especially for high-risk patients.

Keywords: immune-related genes, lncRNAs, lung squamous cell carcinoma, prognostic risk model, immune cell infiltration, immunotherapy

Pubmed Style

Qing Yue, Wei Han, Ziling Liu, Zain Abbas, Akmal Zubair, Saba Beigh, Hayaa Mohammad Alhuthali, Hind A. Alzahrani, Rasha Mohammed Saleem, Nahed S. Alharthi. Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma. JBC Genetics. 2024; 04 (February 2024): 097-105. doi:10.24911/JBCGenetics/183-1674209873

Web Style

Qing Yue, Wei Han, Ziling Liu, Zain Abbas, Akmal Zubair, Saba Beigh, Hayaa Mohammad Alhuthali, Hind A. Alzahrani, Rasha Mohammed Saleem, Nahed S. Alharthi. Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma. https://www.jbcgenetics.com/index.php/articles/2090 [Access: April 27, 2025]. doi:10.24911/JBCGenetics/183-1674209873

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Qing Yue, Wei Han, Ziling Liu, Zain Abbas, Akmal Zubair, Saba Beigh, Hayaa Mohammad Alhuthali, Hind A. Alzahrani, Rasha Mohammed Saleem, Nahed S. Alharthi. Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma. JBC Genetics. (2024), [cited April 27, 2025]; 04 (February 2024): 097-105. doi:10.24911/JBCGenetics/183-1674209873

Harvard Style

Qing Yue, Wei Han, Ziling Liu, Zain Abbas, Akmal Zubair, Saba Beigh, Hayaa Mohammad Alhuthali, Hind A. Alzahrani, Rasha Mohammed Saleem, Nahed S. Alharthi (2024) Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma. JBC Genetics, 04 (February 2024): 097-105. doi:10.24911/JBCGenetics/183-1674209873

Chicago Style

Qing Yue, Wei Han, Ziling Liu, Zain Abbas, Akmal Zubair, Saba Beigh, Hayaa Mohammad Alhuthali, Hind A. Alzahrani, Rasha Mohammed Saleem, Nahed S. Alharthi. "Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma." 04 (2024), 097-105. doi:10.24911/JBCGenetics/183-1674209873

MLA (The Modern Language Association) Style

Qing Yue, Wei Han, Ziling Liu, Zain Abbas, Akmal Zubair, Saba Beigh, Hayaa Mohammad Alhuthali, Hind A. Alzahrani, Rasha Mohammed Saleem, Nahed S. Alharthi. "Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma." 04.February 2024 (2024), 097-105. Print. doi:10.24911/JBCGenetics/183-1674209873

APA (American Psychological Association) Style

Qing Yue, Wei Han, Ziling Liu, Zain Abbas, Akmal Zubair, Saba Beigh, Hayaa Mohammad Alhuthali, Hind A. Alzahrani, Rasha Mohammed Saleem, Nahed S. Alharthi (2024) Construction and validation of an immunity-related prognostic signature for lung squamous cell carcinoma. , 04 (February 2024), 097-105. doi:10.24911/JBCGenetics/183-1674209873