Review Article
Volume: 1 | Issue: 1 | Published: Jan 01, 1970 | Pages: 2 - 9 | DOI: 10.24911/JBCGenetics/183-1531548689
The role of C-terminal tensin-like (Cten) gene in cancer metastasis
Authors:
Saleh Alghamdi
, Sarah Alkwai
, Mohammad Ilyas
Article Info
Authors
Saleh Alghamdi
King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Medical Genomics Research Department, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia
Sarah Alkwai
King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Medical Genomics Research Department, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia
Mohammad Ilyas
Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham Molecular Pathology Node, United Kingdom
Publication History
Received: October 15, 2017
Revised: November 15, 2017
Accepted: December 03, 2017
Published: January 01, 1970
Abstract
C-terminal tensin-like (cten, also known as tensin4, TNS4) is the fourth member of the tensin family. all tensin family members localizes in focal adhesion sites. Cten shares the sequence homology with other tensins at its C-terminal region by having the SH2 and PTB domains. Cten is expressed in some normal tissue such as prostate and placenta while down-regulated in prostate cancer. The overexpression of cten was found associates with tumors of breast, colon, lung, stomach, skin and pancreas. It interacts with growth factors and cytokines as regulators. Also it has been found that cten expression promotes cell motility and enhances tumorigenicity. The collective findings support that cten is having a role in carcinogenesis and promising biomarker. It can be a candidate for a therapeutic target for solid cancers.
Keywords: Cten, colorectal cancer, tensin, metastasis
