JBCGenetics |

Review Article

Published: Jun 25, 2025 | DOI: 10.24911/JBCGenetics.183-1736098649

A gene modifier, circSMARCA5, acts on breast and lung cancer stem cell dynamics and therapeutic targeting

Authors: Awjad Almotari , Bahauddeen M. Alrfaei , Amani A. Alghamedi , Abir A. Alamro

Article Info

Authors

Awjad Almotari

Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia

Bahauddeen M. Alrfaei

King Abdullah International Medical Research Center (KAIMRC), King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Ministry of National Guard, Health Affairs, Riyadh, Saudi Arabia

ORCID

Amani A. Alghamedi

Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia

Abir A. Alamro

Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia

Publication History

Received: January 05, 2025

Accepted: June 17, 2025

Published: June 25, 2025

Abstract

The SWItch/Sucrose Non-Fermentable chromatin remodeling complex, particularly the SMARCA5 gene and its product circSMARCA5, holds significant implications for understanding nucleosomal transformations, gene regulation, and cancer development. Additionally, the concept of cancer stem cells (CSCs) and their role in malignancies sheds light on the complex nature of cancer progression and the potential for targeted therapeutic interventions. The circSMARCA5 expression showed a significant and opposite association with its parent gene in breast cancer, indicating its potential as a therapeutic target for breast cancer treatment. CSCs in breast cancer share similarities with normal stem cells and exhibit disrupted signaling pathways, emphasizing the importance of identifying CSCs for understanding disease biology and developing targeted therapies. Additionally, research revealed circSMARCA5 expression is reduced in nonsmall cell lung cancer (NSCLC), and its overexpression impedes the proliferation, migration, and invasion of NSCLC, indicating its potential as a prognostic indicator for lung cancer patients. The CSCs have been identified in small cell lung cancer, contributing to tumor development, treatment resistance, and potential metastasis through the process of epithelial- mesenchymal transition, and are characterized by the overexpression of specific signaling pathways and cell surface markers. The current understanding of circSMARCA5's role in breast and lung malignancy highlights its significant contribution to tumor development and potential clinical applications, paving the way for promising therapeutic interventions in cancer treatment. This opens new avenues for personalized medicine and novel strategies for cancer management in the future.

Keywords: circSMARCA5, mircoRNAs, cancer stem cell, epigenetic.

Pubmed Style

Awjad Almotari, Bahauddeen M. Alrfaei, Amani A. Alghamedi, Abir A. Alamro. A gene modifier, circSMARCA5, acts on breast and lung cancer stem cell dynamics and therapeutic targeting. JBC Genetics. 2025; 25 (June 2025): -. doi:10.24911/JBCGenetics.183-1736098649

Web Style

Awjad Almotari, Bahauddeen M. Alrfaei, Amani A. Alghamedi, Abir A. Alamro. A gene modifier, circSMARCA5, acts on breast and lung cancer stem cell dynamics and therapeutic targeting. https://www.jbcgenetics.com/articles/2293 [Access: July 31, 2025]. doi:10.24911/JBCGenetics.183-1736098649

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Awjad Almotari, Bahauddeen M. Alrfaei, Amani A. Alghamedi, Abir A. Alamro. A gene modifier, circSMARCA5, acts on breast and lung cancer stem cell dynamics and therapeutic targeting. JBC Genetics. (2025), [cited July 31, 2025]; 25 (June 2025): -. doi:10.24911/JBCGenetics.183-1736098649

Harvard Style

Awjad Almotari, Bahauddeen M. Alrfaei, Amani A. Alghamedi, Abir A. Alamro (2025) A gene modifier, circSMARCA5, acts on breast and lung cancer stem cell dynamics and therapeutic targeting. JBC Genetics, 25 (June 2025): -. doi:10.24911/JBCGenetics.183-1736098649

Chicago Style

Awjad Almotari, Bahauddeen M. Alrfaei, Amani A. Alghamedi, Abir A. Alamro. "A gene modifier, circSMARCA5, acts on breast and lung cancer stem cell dynamics and therapeutic targeting." 25 (2025), -. doi:10.24911/JBCGenetics.183-1736098649

MLA (The Modern Language Association) Style

Awjad Almotari, Bahauddeen M. Alrfaei, Amani A. Alghamedi, Abir A. Alamro. "A gene modifier, circSMARCA5, acts on breast and lung cancer stem cell dynamics and therapeutic targeting." 25.June 2025 (2025), -. Print. doi:10.24911/JBCGenetics.183-1736098649

APA (American Psychological Association) Style

Awjad Almotari, Bahauddeen M. Alrfaei, Amani A. Alghamedi, Abir A. Alamro (2025) A gene modifier, circSMARCA5, acts on breast and lung cancer stem cell dynamics and therapeutic targeting. , 25 (June 2025), -. doi:10.24911/JBCGenetics.183-1736098649