JBCGenetics |

Review Article

Volume: 1 | Issue: 2 | Published: May 18, 2018 | Pages: 57 - 65 | DOI: 10.24911/JBCGenetics/183-1540811228

Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review

Authors: Khalid Siddiqui , Mohthash Musambil , Adnan Mahmood Usmani

Article Info

Authors

Khalid Siddiqui

Strategic Center for Diabetes Research, King Saud University, Riyadh, Saudi Arabia

ORCID

Mohthash Musambil

Strategic Center for Diabetes Research, King Saud University, Riyadh, Saudi Arabia

ORCID

Adnan Mahmood Usmani

Strategic Center for Diabetes Research, King Saud University, Riyadh, Saudi Arabia

Publication History

Received: October 29, 2018

Revised: December 02, 2018

Accepted: January 08, 2019

Published: May 18, 2018

Abstract

Type 2 Diabetes (T2D) is a polygenic and multi-factorial complex disease. The significant challenge of finding genetic markers that could be used to predict T2D risk remains unresolved. Saudi Arabia is one of several ethnicities with a high prevalence rate of T2D. A large number of studies have been performed that explored genetic factors associated with T2D risk. In this work, we conducted a systematic review of published studies on T2D genetic markers in the Saudi population. Multiple databases were employed in the literature review, which focused on studies that either reported the association or non-association of a genetic marker with T2D risk. Using appropriate search terms, we collected, analyzed, and selected 428 articles published between the years of 2000-2018, Of these, 18 articles reported a total of 67 polymorphisms in 46 genes that are strongly linked to T2D in the Saudi population. Most of the relevant studies used genotyping as the primary methodology to identify genetic markers of T2D. Most of these studies were published between the years of 2012-2017. A total of 23 polymorphisms in 17 genes were found to be associated with T2D risk in the Saudi population: KCNJ11, PPARG2, IRS1, VDE, WFS1, JAZF1, CDKN2A/B, TCF7L2, KCNQ1, HNF4A, DUSP9, APOE, HNF1A, SLC30A8, APOC3, SNAP25, and ACE.

Keywords: Type 2 diabetes, Genetics, Saudi Arabia

Pubmed Style

Khalid Siddiqui, Mohthash Musambil, Adnan Mahmood Usmani. Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. JBC Genetics. 2018; 18 (May 2018): 57-65. doi:10.24911/JBCGenetics/183-1540811228

Web Style

Khalid Siddiqui, Mohthash Musambil, Adnan Mahmood Usmani. Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. https://www.jbcgenetics.com/articles/2113 [Access: April 27, 2025]. doi:10.24911/JBCGenetics/183-1540811228

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Khalid Siddiqui, Mohthash Musambil, Adnan Mahmood Usmani. Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. JBC Genetics. (2018), [cited April 27, 2025]; 18 (May 2018): 57-65. doi:10.24911/JBCGenetics/183-1540811228

Harvard Style

Khalid Siddiqui, Mohthash Musambil, Adnan Mahmood Usmani (2018) Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. JBC Genetics, 18 (May 2018): 57-65. doi:10.24911/JBCGenetics/183-1540811228

Chicago Style

Khalid Siddiqui, Mohthash Musambil, Adnan Mahmood Usmani. "Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review." 18 (2018), 57-65. doi:10.24911/JBCGenetics/183-1540811228

MLA (The Modern Language Association) Style

Khalid Siddiqui, Mohthash Musambil, Adnan Mahmood Usmani. "Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review." 18.May 2018 (2018), 57-65. Print. doi:10.24911/JBCGenetics/183-1540811228

APA (American Psychological Association) Style

Khalid Siddiqui, Mohthash Musambil, Adnan Mahmood Usmani (2018) Established Type 2 Diabetes-Susceptibility Genetic Variants in Saudi ethnicity: A Mini-Systematic Review. , 18 (May 2018), 57-65. doi:10.24911/JBCGenetics/183-1540811228