Original Article
Volume: 4 | Issue: 1 | Published: Nov 25, 2020 | Pages: 14 - 21 | DOI: 10.24911/JBCGenetics/183-1598435875
Mannose-binding lectin gene polymorphism in systemic lupus erythematosus nephritis
Authors: Osama Sayed Daif Allah , Alshimaa Hafez Abdelall , Madeha Mahrous Zakhary , Nagwa S. Ahmed , Asmaa Mohamed Goda
Article Info
Authors
Osama Sayed Daif Allah
Physical Medicine, Rheumatology and Rehabilitation, Department, Faculty of Medicine, Sohag University, Egypt
Alshimaa Hafez Abdelall
Medical Biochemistry Department. Faculty of Medicine, Sohag University, Egypt
Madeha Mahrous Zakhary
Medical Biochemistry Department. Faculty of Medicine, Assuit University, Egypt
Nagwa S. Ahmed
Medical Biochemistry Department. Faculty of Medicine, Sohag University, Egypt
Asmaa Mohamed Goda
Medical Microbiology and Immunology Department, Faculty of Medicine, Sohag University, Egypt
Publication History
Received: January 01, 1970
Revised: September 22, 2020
Accepted: September 25, 2020
Published: November 25, 2020
Abstract
Background: Systemic lupus erythematosus (SLE) is a complex trait characterized by the production of a range of autoantibodies and a diverse set of clinical phenotypes, including skin rash, neuropsychiatric and musculoskeletal symptoms, and lupus nephritis (LN). Mannan-binding lectin (MBL) is a recognition molecule of the lectin pathway of complement activation. We investigated MBL gene polymorphism at exon 1 codon 54 as a potential biomarker for SLE nephritis in the current study. Methodology: A caseĀcontrol study screened 70 participants. They were included in the study from the outpatient clinic or the inpatient section of the Rheumatology Department at Sohag University Hospital during July 2017-June 2019 for MBL gene polymorphism at exon 1 codon 54, which was detected by polymerase chain reaction using sequence-specific priming. Result: There was a predominance of AA (wild) genotype in the control group (40%). Patient groups had a statistically significant equal higher frequency of heterozygous polymorphism (AB) (76%) than the controls. BB genotype showed a statistically significant lowest frequency in the LN group (p-value = 0.04). Conclusions: MBL AB genotyping was more frequent in SLE patients either with or without nephritis than in the normal Egyptian population. BB genotyping was less frequent in LN patients than in patients without nephritis. The present study supports that the carriage of MBL AB genotype (heterozygous polymorphism at codon 54) was associated with both SLE and LN development in normal Egyptians.
Keywords: Mannose-binding lectin (MBL), systemic lupus erythematosus (SLE), lupus nephritis (LN), gene polymorphism
Pubmed Style
Osama Sayed Daif Allah, Alshimaa Hafez Abdelall, Madeha Mahrous Zakhary, Nagwa S. Ahmed, Asmaa Mohamed Goda. Mannose-binding lectin gene polymorphism in systemic lupus erythematosus nephritis. JBC Genetics. 2020; 25 (November 2020): 14-21. doi:10.24911/JBCGenetics/183-1598435875
Web Style
Osama Sayed Daif Allah, Alshimaa Hafez Abdelall, Madeha Mahrous Zakhary, Nagwa S. Ahmed, Asmaa Mohamed Goda. Mannose-binding lectin gene polymorphism in systemic lupus erythematosus nephritis. https://www.jbcgenetics.com/articles/2124 [Access: April 27, 2025]. doi:10.24911/JBCGenetics/183-1598435875
AMA (American Medical Association) Style
Osama Sayed Daif Allah, Alshimaa Hafez Abdelall, Madeha Mahrous Zakhary, Nagwa S. Ahmed, Asmaa Mohamed Goda. Mannose-binding lectin gene polymorphism in systemic lupus erythematosus nephritis. JBC Genetics. 2020; 25 (November 2020): 14-21. doi:10.24911/JBCGenetics/183-1598435875
Vancouver/ICMJE Style
Osama Sayed Daif Allah, Alshimaa Hafez Abdelall, Madeha Mahrous Zakhary, Nagwa S. Ahmed, Asmaa Mohamed Goda. Mannose-binding lectin gene polymorphism in systemic lupus erythematosus nephritis. JBC Genetics. (2020), [cited April 27, 2025]; 25 (November 2020): 14-21. doi:10.24911/JBCGenetics/183-1598435875
Harvard Style
Osama Sayed Daif Allah, Alshimaa Hafez Abdelall, Madeha Mahrous Zakhary, Nagwa S. Ahmed, Asmaa Mohamed Goda (2020) Mannose-binding lectin gene polymorphism in systemic lupus erythematosus nephritis. JBC Genetics, 25 (November 2020): 14-21. doi:10.24911/JBCGenetics/183-1598435875
Chicago Style
Osama Sayed Daif Allah, Alshimaa Hafez Abdelall, Madeha Mahrous Zakhary, Nagwa S. Ahmed, Asmaa Mohamed Goda. "Mannose-binding lectin gene polymorphism in systemic lupus erythematosus nephritis." 25 (2020), 14-21. doi:10.24911/JBCGenetics/183-1598435875
MLA (The Modern Language Association) Style
Osama Sayed Daif Allah, Alshimaa Hafez Abdelall, Madeha Mahrous Zakhary, Nagwa S. Ahmed, Asmaa Mohamed Goda. "Mannose-binding lectin gene polymorphism in systemic lupus erythematosus nephritis." 25.November 2020 (2020), 14-21. Print. doi:10.24911/JBCGenetics/183-1598435875
APA (American Psychological Association) Style
Osama Sayed Daif Allah, Alshimaa Hafez Abdelall, Madeha Mahrous Zakhary, Nagwa S. Ahmed, Asmaa Mohamed Goda (2020) Mannose-binding lectin gene polymorphism in systemic lupus erythematosus nephritis. , 25 (November 2020), 14-21. doi:10.24911/JBCGenetics/183-1598435875