JBCGenetics |

Original Article

Volume: 5 | Issue: 2 | Published: Dec 16, 2022 | Pages: 37 - 42 | DOI: 10.24911/JBCGenetics/183-1664872492

Genetic impact of non-consanguineous marriages in Saudi Arabia.

Authors: Mohammed Alyahya , Taghrid Aloraini , Youseef Al-Harbi , Lamia Alsubaie , Abdulrahman Alswaid , Wafaa Eyaid , Fuad Al Mutairi , Faroug Ababneh , Majid Alfadhel , Ahmed Alfares

Article Info

Authors

Mohammed Alyahya

Center for Genomic Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia,Agency for Allied Health Services, Ministry of Health

Taghrid Aloraini

Division of Translational Pathology, Department of Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia,King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

Youseef Al-Harbi

Lamia Alsubaie

Department of Genetics and Precision Medicine, King Abdullah Specialized Children Hospital, King Abdulaziz Medical City, MNGHA, Riyadh, Saudi Arabia,King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

Abdulrahman Alswaid

Wafaa Eyaid

Fuad Al Mutairi

Faroug Ababneh

Majid Alfadhel

Ahmed Alfares

Center for Genomic Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia,Division of Translational Pathology, Department of Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia,King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Publication History

Received: October 04, 2022

Revised: November 03, 2022

Accepted: November 15, 2022

Published: December 16, 2022

Abstract

Background: Physicians and geneticists face challenges in making accurate diagnoses during clinical evaluations; affecting patients and clinicians. The aim of this study was to estimate the hit rate of the non-consanguineous population. Moreover, prevalence of the genetic disorder in both the consanguineous and non- consanguineous population of Saudi Arabia at King Abdulaziz Medical City in Riyadh data. Methods: We reviewed 681 families and 1563 individuals with 2,565,335 variants in the King Abdullah International Medical Research Center (KAIMRC) Genomic Database (KGD), Riyadh, Saudi Arabia. All the ES requests were obtained from the physician and clinical geneticist of KAIMRC, and the test was performed either in-house or in a College of American Pathologists accredited laboratory center for clinical purposes. Results: A total of 151 non-consanguineous individuals with exome sequencing requests in the population genomic database of King Abdullah International Medical Research Center was considered for the study. In total, 27 had disease-causing variants, and the hit rate was 27/151 (18%). Among the 28 different variants in the 27 individuals, 50% were de novo variants and 50% inherited. The hit rate of the variants causing autosomal recessive disorders was 12/28 (42.8%), autosomal dominant disorders 13/28 (46.4%), and X-linked disorders 3/28 (10.7%). Conclusion: Non-consanguineous marriages have a lower risk of genetic disorders, and reducing consanguinity reduces the risk of genetic disorders by two to three times.

Keywords: Saudi Arabia, non-consanguineous, ES, hit rate

Pubmed Style

Mohammed Alyahya, Taghrid Aloraini, Youseef Al-Harbi, Lamia Alsubaie, Abdulrahman Alswaid, Wafaa Eyaid, Fuad Al Mutairi, Faroug Ababneh, Majid Alfadhel, Ahmed Alfares. Genetic impact of non-consanguineous marriages in Saudi Arabia.. JBC Genetics. 2022; 16 (December 2022): 37-42. doi:10.24911/JBCGenetics/183-1664872492

Web Style

Mohammed Alyahya, Taghrid Aloraini, Youseef Al-Harbi, Lamia Alsubaie, Abdulrahman Alswaid, Wafaa Eyaid, Fuad Al Mutairi, Faroug Ababneh, Majid Alfadhel, Ahmed Alfares. Genetic impact of non-consanguineous marriages in Saudi Arabia.. https://www.jbcgenetics.com/articles/2106 [Access: April 27, 2025]. doi:10.24911/JBCGenetics/183-1664872492

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Mohammed Alyahya, Taghrid Aloraini, Youseef Al-Harbi, Lamia Alsubaie, Abdulrahman Alswaid, Wafaa Eyaid, Fuad Al Mutairi, Faroug Ababneh, Majid Alfadhel, Ahmed Alfares. Genetic impact of non-consanguineous marriages in Saudi Arabia.. JBC Genetics. (2022), [cited April 27, 2025]; 16 (December 2022): 37-42. doi:10.24911/JBCGenetics/183-1664872492

Harvard Style

Mohammed Alyahya, Taghrid Aloraini, Youseef Al-Harbi, Lamia Alsubaie, Abdulrahman Alswaid, Wafaa Eyaid, Fuad Al Mutairi, Faroug Ababneh, Majid Alfadhel, Ahmed Alfares (2022) Genetic impact of non-consanguineous marriages in Saudi Arabia.. JBC Genetics, 16 (December 2022): 37-42. doi:10.24911/JBCGenetics/183-1664872492

Chicago Style

Mohammed Alyahya, Taghrid Aloraini, Youseef Al-Harbi, Lamia Alsubaie, Abdulrahman Alswaid, Wafaa Eyaid, Fuad Al Mutairi, Faroug Ababneh, Majid Alfadhel, Ahmed Alfares. "Genetic impact of non-consanguineous marriages in Saudi Arabia.." 16 (2022), 37-42. doi:10.24911/JBCGenetics/183-1664872492

MLA (The Modern Language Association) Style

Mohammed Alyahya, Taghrid Aloraini, Youseef Al-Harbi, Lamia Alsubaie, Abdulrahman Alswaid, Wafaa Eyaid, Fuad Al Mutairi, Faroug Ababneh, Majid Alfadhel, Ahmed Alfares. "Genetic impact of non-consanguineous marriages in Saudi Arabia.." 16.December 2022 (2022), 37-42. Print. doi:10.24911/JBCGenetics/183-1664872492

APA (American Psychological Association) Style

Mohammed Alyahya, Taghrid Aloraini, Youseef Al-Harbi, Lamia Alsubaie, Abdulrahman Alswaid, Wafaa Eyaid, Fuad Al Mutairi, Faroug Ababneh, Majid Alfadhel, Ahmed Alfares (2022) Genetic impact of non-consanguineous marriages in Saudi Arabia.. , 16 (December 2022), 37-42. doi:10.24911/JBCGenetics/183-1664872492