JBCGenetics |

Original Article

Volume: 6 | Issue: 1 | Published: Feb 08, 2023 | Pages: 14 - 21 | DOI: 10.24911/JBCGenetics/183-1670609060

Erythropoietin resistance in patients with regular hemodialysis in Sohag university hospital

Authors: Nagwa S. Ahmed , Aida A Mahmoud , Nayel Abd Elhamed Zaki , Amera A. Genedy

Article Info

Authors

Nagwa S. Ahmed

Medical Biochemistry Department, Faculty of Medicine, Sohag University,Sohag, Egypt

ORCID

Aida A Mahmoud

Medical Biochemistry Department, Faculty of Medicine, Sohag University,Sohag, Egypt

Nayel Abd Elhamed Zaki

Department of Internal Medicine and Cardiology, Faculty of Medicine, Sohag University,Sohag, Egypt

Amera A. Genedy

Medical Biochemistry Department, Faculty of Medicine, Sohag University,Sohag, Egypt.

Publication History

Received: December 09, 2022

Revised: January 22, 2023

Accepted: January 23, 2023

Published: February 08, 2023

Abstract

Background: A definite anemia [hemoglobin (HB) 10-12 g/dl] or the need for significantly higher Erythropoietin (EPO) dosages of epoetin alfa are symptoms of EPO resistance, respectively. The recommended restorative goal is to maintain HB levels between 11 and 12 g/dl. Fe deficiency, concurrent inflammation, inadequate dialysis, hyperparathyroidism, hemolysis, vitamin B12, and folate deficiency are the main causes of EPO resistance. The objective of this study was to evaluate patients who receive frequent hemodialysis for EPO resistance. Methods: This study was performed at Sohag University Hospital on 50 hemodialysis patients compared to 40 healthy adult subjects from June 2021 to January 2022. Serum EPO was analyzed by enzyme-linked immunosorbent assay and Angiotensin Converting Enzyme (ACE) rs1799752 polymorphism was assessed using the Genomic TaqMan genotyping test. Results: This study found insignificant relation between EPO Resistance Index (ERI) and diverse ACE genotype groups and para thyroid hormone. A further significant direct proportional relationship was found between ERI and Ferritin. EPO and parathyroid hormone did not show any significant relationship. Conclusion: Considering the non-critical connection between ERI and our components, it is vital to enhance the treatment of anemic patients with chronic kidney diseases to recognize the potential causes of resistance and ponder other variables for resistance before proposing an expanded EPO-stimulating agent administration.

Keywords: Erythropoietin, hemodialysis, erythropoietin resistance index, erythropoietin stimulating agents

Pubmed Style

Nagwa S. Ahmed, Aida A Mahmoud, Nayel Abd Elhamed Zaki, Amera A. Genedy. Erythropoietin resistance in patients with regular hemodialysis in Sohag university hospital. JBC Genetics. 2023; 08 (February 2023): 14-21. doi:10.24911/JBCGenetics/183-1670609060

Web Style

Nagwa S. Ahmed, Aida A Mahmoud, Nayel Abd Elhamed Zaki, Amera A. Genedy. Erythropoietin resistance in patients with regular hemodialysis in Sohag university hospital. https://www.jbcgenetics.com/articles/2078 [Access: April 27, 2025]. doi:10.24911/JBCGenetics/183-1670609060

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Nagwa S. Ahmed, Aida A Mahmoud, Nayel Abd Elhamed Zaki, Amera A. Genedy. Erythropoietin resistance in patients with regular hemodialysis in Sohag university hospital. JBC Genetics. (2023), [cited April 27, 2025]; 08 (February 2023): 14-21. doi:10.24911/JBCGenetics/183-1670609060

Harvard Style

Nagwa S. Ahmed, Aida A Mahmoud, Nayel Abd Elhamed Zaki, Amera A. Genedy (2023) Erythropoietin resistance in patients with regular hemodialysis in Sohag university hospital. JBC Genetics, 08 (February 2023): 14-21. doi:10.24911/JBCGenetics/183-1670609060

Chicago Style

Nagwa S. Ahmed, Aida A Mahmoud, Nayel Abd Elhamed Zaki, Amera A. Genedy. "Erythropoietin resistance in patients with regular hemodialysis in Sohag university hospital." 08 (2023), 14-21. doi:10.24911/JBCGenetics/183-1670609060

MLA (The Modern Language Association) Style

Nagwa S. Ahmed, Aida A Mahmoud, Nayel Abd Elhamed Zaki, Amera A. Genedy. "Erythropoietin resistance in patients with regular hemodialysis in Sohag university hospital." 08.February 2023 (2023), 14-21. Print. doi:10.24911/JBCGenetics/183-1670609060

APA (American Psychological Association) Style

Nagwa S. Ahmed, Aida A Mahmoud, Nayel Abd Elhamed Zaki, Amera A. Genedy (2023) Erythropoietin resistance in patients with regular hemodialysis in Sohag university hospital. , 08 (February 2023), 14-21. doi:10.24911/JBCGenetics/183-1670609060