JBCGenetics |

Review Article

Volume: 4 | Issue: 1 | Published: Nov 19, 2020 | Pages: 42 - 47 | DOI: 10.24911/JBCGenetics/183-1597317668

The association between IVF and chromosomal abnormalities compared to spontaneous conception

Authors: Sawsan Alharthi , Lama Alrasheed , Ghada Alrashed , Ghaida Almutairi , Marwan Nashabat , Majid Alfadhel

Authors

Sawsan Alharthi

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City Ministry of National Guard-Health Affairs (MNG-HA), Riyadh, Saudi Arabia

Lama Alrasheed

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City Ministry of National Guard-Health Affairs (MNG-HA), Riyadh, Saudi Arabia

Ghada Alrashed

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City Ministry of National Guard-Health Affairs (MNG-HA), Riyadh, Saudi Arabia

Ghaida Almutairi

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City Ministry of National Guard-Health Affairs (MNG-HA), Riyadh, Saudi Arabia

Marwan Nashabat

Medical Genetics Division, Department of Pediatrics, King Abdulaziz Medical City Ministry of National Guard-Health Affairs (MNG-HA), Riyadh, Saudi Arabia

Majid Alfadhel

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City Ministry of National Guard-Health Affairs (MNG-HA), Riyadh, Saudi Arabia

Publication History

Received: August 13, 2020

Revised: October 18, 2020

Accepted: October 28, 2020

Published: November 19, 2020

Abstract

In vitro fertilization (IVF) is a process by which an egg is extracted by needle aspiration and then combined with a sperm so that fertilization can occur outside the body. Genetic defects, such as chromosomal abnormalities, are considered rare among the general population; however, even though their incidence among IVF-conceived children is uncommon, several alarming studies were published on the increased risk of chromosomal abnormalities IVF/intracytoplasmic sperm injection (ICSI)-conceived children compared to universal rates. This study aimed to review the literature and present data to answer whether IVF or ICSI is associated with an increased risk of chromosomal abnormalities inborn after IVF/ICSI treatment compared to spontaneously conceived children. Relevant published scientific articles were searched in the Medline database, using combinations of the following key terms: "IVF", "in vitro fertilization", "ICSI", "intracytoplasmic sperm injection", "natural conception", "spontaneous conception" along with "chromosomal abnormalities", "chromosomal defects", "sex chromosome aneuploidy", and "trisomy". The eligible studies were considered as studies exploring the association of IVF/ICSI with chromosomal abnormalities compared to spontaneous conception. The search included studies published from 1992 to 2018. The results for the association of chromosomal abnormalities and IVF remain unclear. As many studies proved a significant increase in chromosomal abnormalities and syndromes among the IVF population, other studies were contradicting and contributed the abnormalities to several environmental and technical factors.

Keywords: IVF, ICSI, spontaneous conception, chromosomal abnormalities, sex chromosome aneuploidy, trisomy

Pubmed Style

Sawsan Alharthi, Lama Alrasheed, Ghada Alrashed, Ghaida Almutairi, Marwan Nashabat, Majid Alfadhel. The association between IVF and chromosomal abnormalities compared to spontaneous conception. JBC Genetics. 2020; 19 (November 2020): 42-47. doi:10.24911/JBCGenetics/183-1597317668

Web Style

Sawsan Alharthi, Lama Alrasheed, Ghada Alrashed, Ghaida Almutairi, Marwan Nashabat, Majid Alfadhel. The association between IVF and chromosomal abnormalities compared to spontaneous conception. https://www.jbcgenetics.com/articles/2128 [Access: April 27, 2025]. doi:10.24911/JBCGenetics/183-1597317668

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Sawsan Alharthi, Lama Alrasheed, Ghada Alrashed, Ghaida Almutairi, Marwan Nashabat, Majid Alfadhel. The association between IVF and chromosomal abnormalities compared to spontaneous conception. JBC Genetics. (2020), [cited April 27, 2025]; 19 (November 2020): 42-47. doi:10.24911/JBCGenetics/183-1597317668

Harvard Style

Sawsan Alharthi, Lama Alrasheed, Ghada Alrashed, Ghaida Almutairi, Marwan Nashabat, Majid Alfadhel (2020) The association between IVF and chromosomal abnormalities compared to spontaneous conception. JBC Genetics, 19 (November 2020): 42-47. doi:10.24911/JBCGenetics/183-1597317668

Chicago Style

Sawsan Alharthi, Lama Alrasheed, Ghada Alrashed, Ghaida Almutairi, Marwan Nashabat, Majid Alfadhel. "The association between IVF and chromosomal abnormalities compared to spontaneous conception." 19 (2020), 42-47. doi:10.24911/JBCGenetics/183-1597317668

MLA (The Modern Language Association) Style

Sawsan Alharthi, Lama Alrasheed, Ghada Alrashed, Ghaida Almutairi, Marwan Nashabat, Majid Alfadhel. "The association between IVF and chromosomal abnormalities compared to spontaneous conception." 19.November 2020 (2020), 42-47. Print. doi:10.24911/JBCGenetics/183-1597317668

APA (American Psychological Association) Style

Sawsan Alharthi, Lama Alrasheed, Ghada Alrashed, Ghaida Almutairi, Marwan Nashabat, Majid Alfadhel (2020) The association between IVF and chromosomal abnormalities compared to spontaneous conception. , 19 (November 2020), 42-47. doi:10.24911/JBCGenetics/183-1597317668