JBCGenetics |

Original Article

Volume: 4 | Issue: 1 | Published: Jan 17, 2021 | Pages: 35 - 41 | DOI: 10.24911/JBCGenetics/183-1606168933

Do we know properly young age breast cancer patients: a double centre study

Authors: Hale Onder Yilmaz , Halil Tadkaynatan , Mustafa Gokoglu , Orkun Yilmaz , Gokmen Aktas

Article Info

Authors

Hale Onder Yilmaz

Kahramanmaras Necip Fazıl City Hospital, Department of Medical Genetics, Kahramanmaras, Turkey

ORCID

Halil Tadkaynatan

Kahramanmaras Necip Fazıl City Hospital, Department of Medical Oncology, Kahramanmaras, Turkey

ORCID

Mustafa Gokoglu

Kahramanmaras Necip Fazıl City Hospital, Department of Medical Genetics, Kahramanmaras, Turkey

ORCID

Orkun Yilmaz

Kahramanmaras Necip Fazıl City Hospital, Department of Orthopaedics and Traumatology, Kahramanmaras, Turkey

ORCID

Gokmen Aktas

Kahramanmaras Sutcu Imam University, Department of Medical Oncology, Kahramanmaras, Turkey

ORCID

Publication History

Received: November 23, 2020

Revised: December 10, 2020

Accepted: December 18, 2020

Published: January 17, 2021

Abstract

Background: According to American Cancer Society, an estimated 268,600 new cases of invasive breast cancer was diagnosed among women, and nearly 50,000 women were under age 50 years. Therefore, the identification of young age breast cancer patients can have a collosal impact on treatment, and medical follow-up. The present study aimed to understand the young age breast cancer pathophysiology and redound new BRCA variants to literature. Methodology: This was a double-centre study performed in the Medical Genetics Department of Kahramanmaras Necip Fazıl City Hospital. In this study, sixty female patients, who are under 45 years old, diagnosed with primer breast cancer in the oncology clinic of the same hospital and Kahramanmaraş Sutcu İmam University were included. The patients were selected for BRCA mutation testing based on NCCN Guideline Version 3.2019 BRCA1/2 Testing Criteria. Relatives who meet the same criteria from the same family were not included to prevent repetition. Patients with known other cancer syndromes were also excluded. Results: We found that Luminal-B type breast cancer was the most frequent subtype (p < 0.001), patients with Luminal-A subtype breast cancer had significantly smaller tumor size and smaller grade than those had other subtypes of breast cancer at diagnosis stage (p = 0.03 and p < 0.001, respectively). Regarding tumor localization, the breast carcinomas were mostly localized in the right breast (53.3%). Two patients (3.3%) had BRCA1 pathogenic mutation and five patients (8.3%) had BRCA2 pathogenic mutation. Additionally, we found two new variations in BRCA2 gene (c.478_488delGTATGTGGGAG and c.8830 A>T (rs4987047). All BRCA1/2 MLPA results were normal. Conclusion: The incidence of young age breast cancer varies among countries, and it is higher in developing countries. Understanding of young age breast cancer cases will be helpful to provide suitable treatment options and will help to reduce the death rate of these patients.

Keywords: Young age breast cancer, BRCA1, BRCA2

Pubmed Style

Hale Onder Yilmaz, Halil Tadkaynatan, Mustafa Gokoglu, Orkun Yilmaz, Gokmen Aktas. Do we know properly young age breast cancer patients: a double centre study. JBC Genetics. 2021; 17 (January 2021): 35-41. doi:10.24911/JBCGenetics/183-1606168933

Web Style

Hale Onder Yilmaz, Halil Tadkaynatan, Mustafa Gokoglu, Orkun Yilmaz, Gokmen Aktas. Do we know properly young age breast cancer patients: a double centre study. https://www.jbcgenetics.com/articles/2127 [Access: April 27, 2025]. doi:10.24911/JBCGenetics/183-1606168933

AMA (American Medical Association) Style

Vancouver/ICMJE Style

Hale Onder Yilmaz, Halil Tadkaynatan, Mustafa Gokoglu, Orkun Yilmaz, Gokmen Aktas. Do we know properly young age breast cancer patients: a double centre study. JBC Genetics. (2021), [cited April 27, 2025]; 17 (January 2021): 35-41. doi:10.24911/JBCGenetics/183-1606168933

Harvard Style

Hale Onder Yilmaz, Halil Tadkaynatan, Mustafa Gokoglu, Orkun Yilmaz, Gokmen Aktas (2021) Do we know properly young age breast cancer patients: a double centre study. JBC Genetics, 17 (January 2021): 35-41. doi:10.24911/JBCGenetics/183-1606168933

Chicago Style

Hale Onder Yilmaz, Halil Tadkaynatan, Mustafa Gokoglu, Orkun Yilmaz, Gokmen Aktas. "Do we know properly young age breast cancer patients: a double centre study." 17 (2021), 35-41. doi:10.24911/JBCGenetics/183-1606168933

MLA (The Modern Language Association) Style

Hale Onder Yilmaz, Halil Tadkaynatan, Mustafa Gokoglu, Orkun Yilmaz, Gokmen Aktas. "Do we know properly young age breast cancer patients: a double centre study." 17.January 2021 (2021), 35-41. Print. doi:10.24911/JBCGenetics/183-1606168933

APA (American Psychological Association) Style

Hale Onder Yilmaz, Halil Tadkaynatan, Mustafa Gokoglu, Orkun Yilmaz, Gokmen Aktas (2021) Do we know properly young age breast cancer patients: a double centre study. , 17 (January 2021), 35-41. doi:10.24911/JBCGenetics/183-1606168933